Multiple Sclerosis Health Topic

Learn More About Multiple Sclerosis

1. Multiple Sclerosis Journal Article Virtual Library

   Recommended resource. Contains over 500 published scientific articles related to multiple sclerosis, with an emphasis on nutritional factors and MS.

2. The Pathogenesis of Multiple Sclerosis Revisited

   The cause of MS is unknown, as is the exact pathogenesis of the disorder. In recent years, most researchers have uncritically accepted the hypothesis that it is an autoimmune disorder. An in-depth review of the literature failed to support this concept. There is a common recurring statement in virtually every paper and textbook that MS is of autoimmune aetiology. It has been assumed (but never proven) that a ... T-cell driven immune mechanism is responsible for demyelination in MS. No specific or sensitive immunological test exists that is diagnostic of MS despite the extensive application of modern technology. Critical analysis of the epidemiological data shows no association with any specific autoimmune diseases. Immunosuppression has failed to have any consistent effect on prognosis or disease progression.

   SCIENTIFIC STUDY

3. The Paleolithic Diet and Multiple Sclerosis

   The diet was first popularised by film writer Roger MacDougall. The broad basis of MacDougall's diet is: no foods that contains gluten, no foods that contain dairy produce, low sugars, in particular, no refined sugar, low animal fats, high unsaturated fats, no foods to which you are allergic, and vitamin and mineral supplements to counter any deficiencies.

4. Regimen to Promote Neuroprotection and Encourage Nerve Repair

   Suggested regimen to help quell inflammation and promote nerve repair in various neurodegenerative and neuroinflammatory diseases and disorders plus a compendium of resources and promising adjunctive therapeutic agents for Multiple Sclerosis and other neurological diseases and disorders.

5. Uses of Aloe Products, e.g. Acemannan, in the Treatment of Diseases Requiring Intervention of the Immune System for Cure

   Acemannan has been shown to be effective in treating a number of conditions where the principal mechanism of resolution or cure requires intervention by the patient's immune system. Acemannan has direct stimulatory effects on the immune system. In addition, acemannan directly interacts with virus or other infectious organisms, infected cells, and tumor cells to produce changes in their immunologically sensitive surface composition to alter the appearance of these agents and cause them to be recognized by the body's immune system and then destroyed. This document contains 51 examples on research and studies of acemannan for wide range of diseases including multiple sclerosis (17). The patient...began taking approximately 500 mg oral acemannan daily. The patient observed no change in the status of the disease until about 10 weeks had elapsed at which time she reported feeling better than at any time in the previous year. Two weeks later she was able to walk longer distances using the walker and in one more month was able to walk with the use of only a cane. The patient has maintained this level for more than 10 months while continuing to consume about 500 mg acemannan per day with no other concurrent therapy. Another patient] was started on 800 mg/day oral acemannan and an extensive exercise program. Six weeks after therapy initiation, she was able to go on an ocean cruise with limited physical support. At 6 months she reported that her neurologist indicated that plaques visualized by NMR techniques had regressed.

   PATENT APPLICATION

6. Administration of Acemannan

   Example 28: The antiviral properties of acemannan noted in tissue cultures, animals, and humans led to the early effort to investigate whether multiple sclerosis would respond to an immune modulating complex polysaccharide. Nerve growth factor (NGF) is released by activated monocytes under induction by LPS. Mannans are the biologically active moiety in L.P.S., as in acemannan. Activated neurite processes extend from neurons to induce Schwann cells to produce myelin to encircle and restore neural impulse transmission to injured and non-functional nerves. This latter sequence of events, induced by acemannan, undoubtedly is active in the repair and restoration of multiple sclerosis patient nerve function. The return of nerve function in M.S. patients treated with acemannan follows the classical progression of return of nerve function seen in selected cord lesions applied experimentally in animals and seen in human trauma.

   PATENT APPLICATION

7. Curry Spice May Fight Multiple Sclerosis

   Interest in the potential neuroprotective properties of curcumin rose after studies found very low levels of neurological diseases such as Alzheimer's in elderly Indian populations. Just how curcumin might work to thwart the progression of demyelinization remains unclear. Researchers believe it may interrupt the production of IL-12, a protein that plays a key role in signaling immune cells to launch their assault on the myelin sheath.

8. Starvation Could Relieve Multiple Sclerosis

   Fat cells release leptin after a meal to curb the appetite, and it also alters immune function. In the mouse MS model, just before the onset of disease, the animals' leptin levels doubled. But in mice that ate nothing for 48 hours - the equivalent of 7 to 10 days for humans - the leptin surge was smaller. Leptin is upregulated during inflammatory or immune responses.

9. Gray Matter Damage in the Brain of MS Patients Linked to Cognitive, Physical Deficits

   The mental impairment and problems with walking experienced by patients with multiple sclerosis are linked to damage in the brain's gray matter, with MRI findings suggesting the damage is due to toxic deposits of iron, researchers from the University at Buffalo have shown for the first time. Previous breakthrough work by the team had linked deep gray matter iron deposits to the disease course of MS, brain atrophy and overall disability.

10. Electromagnetic Hypersensitivity: Biological Effects of Dirty Electricity with Emphasis on Diabetes and Multiple Sclerosis.

    The connection between electromagnetic pollution and these disorders needs to be investigated. Several case studies and anecdotal reports are presented.

11. Multiple Sclerosis Best Bet Treatment

    The treatment which is suggested in this essay assumes that dietary factors are the main cause of MS onset and progression. The basic elements of a dietary model for MS are the escape of intact food proteins through a leaky gut and subsequent activation of the immune system. The immune system is activated against tissue in the central nervous system due to molecular similarities between the food proteins and self-proteins in the CNS.

    CONTAINS REFERNECES

12. Best Bet Diet Support Group

    Website for Ashton Embry's Best Bet diet plan for multiple sclerosis.

13. Direct-MS Recommended Supplement List

    List of vitamins, minerals, antioxidants, probiotics and other supplements.

14. Biological Effect of Velvet Antler Polypeptides on Neural Stem Cells

    Velvet antler polypeptides (VAPs), which are derived from the antler velvets, have been reported to maintain survival and promote growth and differentiation of neural cells and, especially the development of neural tissues. Neural stem cells can be successfully induced into neurons by VAPs in vitro, which could provide a basis for regeneration of the nervous system.

    SCIENTIFIC STUDY

15. Repairing the Nervous System: Multiple Sclerosis and Remyelination

    Axons extend out from neurons like cables, transmitting messages in the form of electrical signals from one neuron to another, thereby enabling the brain to conduct its functions. Wrapped around the axons, the myelin sheath protects and supports axons and enables efficient signal transmission. Without myelin, the brain functions they support become impaired. This process is called demyelination and is the primary destructive process in MS.

16. The Influence of Hericium Erinaceus Extract on Myelination Process

    Recently it was shown that extract from mushroom Hericium erinaceus had activating action on the nerve tissue. The process of myelination in the presence of the extract began earlier as compared to controls and was characterised by a higher rate. Thus, extract of H. erinaceus promoted normal development of cultivated cerebellar cells and demonstrated a regulatory effect on the process of myelin genesis process in vitro.

17. The Ultimate Guide to Herbs for MS

    The 33 top herb supplements for MS and what they offer.

18. Dietary Supplement Acetyl-L-Carnitine May Reduce Fatigue in Multiple Sclerosis

    Acetyl-L-carnitine is a form of L-carnitine, an amino acid that is found in nearly all cells of the body. L-carnitine plays a critical role in the production of energy from long-chain fatty acids. In addition, it increases the activity of certain nerve cells in the central nervous system. Some research suggests that acetyl-L-carnitine can improve fatigue associated with multiple sclerosis.

19. Cannabinoids and Multiple Sclerosis

    Cannabis and individual cannabinoids may be effective in suppressing certain symptoms of multiple sclerosis and spinal cord injury, including spasticity and pain.

20. Dr. Klenner's Protocol for Multiple Sclerosis

    Frederich Klenner defines an orthomolecular treatment of MS.

21. Response of Peripheral and Central Nerve Pathology to Mega-Doses of the Vitamin B-Complex and Other Metabolites

    Niacin dilates the blood vessels, even those that have been compressed by scar tissue, allowing a greater amount of nutrient material to reach the cell laboratory or factor comprising muscles and nerves.

22. The Directory of Multiple Sclerosis Alternatives

    A worldwide collection of websites that deal wholly or in part with alternative approaches to treating multiple sclerosis.

23. MS Breakthrough

    Dr. Zamboni's research suggests that MS is not, as widely believed, an autoimmune condition, but a vascular disease. He found repeated references, dating back a century, to excess iron as a possible cause of MS. The heavy metal can cause inflammation and cell death. Dr. Zamboni made a startling find: in more than 90 per cent of people with multiple sclerosisthe veins draining blood from the brain were malformed or blocked. He hypothesized that iron was damaging the blood vessels and allowing the heavy metal, along with other unwelcome cells, to cross the crucial brain-blood barrier. When Dr. Zamboni performed a simple operation to unclog veins and get blood flowing normally again, many of the symptoms of MS disappeared.

24. From MS Patients, Outcry for Unproved Treatment

    Pressure from activists helped persuade the Multiple Sclerosis Society to pay for studies of Dr. Zamboni’s theory. The Multiple Sclerosis Societies in the United States and Canada will spend $2.4 million over the next two years on studies at seven centers. Researchers in Buffalo have confirmed (but not yet published) that narrowed veins and abnormal blood flow are more common in people with multiple sclerosis.

25. Controversial MS Treatment Lessens Fatigue

    Multiple sclerosis patients may get some relief from severe fatigue from an experimental procedure to open blocked blood vessels in the chest and neck. Dr. Zamboni theorizes that abnormal blood flow can damage the nervous system and lead to MS. He reported initial results in 2009, suggesting the existence of CCSVI and that endovascular treatment relieved some MS symptoms and improved quality of life in certain MS patients.Treatment for chronic cerebrospinal venous insufficiency (CCSVI) is controversial, with some doctors doubting the existence of the condition.

26. Chronic Cerebrospinal Venous Insufficiency (CCSVI)

    Links about CCSVI research.

27. Serum Uric Acid and Multiple Sclerosis

    Several studies indicate that patients with multiple sclerosis have low serum levels of the endogenous antioxidant uric acid.

    SCIENTIFIC STUDY

28. High Doses of Vitamin D Cut MS Relapses

    Study shows Vitamin D may help reduce relapse rate of multiple sclerosis.People taking high doses of vitamin D did not suffer any significant side effects.

29. Low Dose Naltrexone (LDN) as a Treatment for Multiple Sclerosis

    Naltrexone is an opiate antagonist, and at the usual dosage of 50 to 100 mg, is used to help people stop abusing alcohol or narcotics (opioid drugs). Low dose naltrexone refers to the "off-label" use of naltrexone at a fraction of the usual dose, which is thought to help MS through a possible variety of mechanisms, including increasing sensitivity to endorphins, reducing inflammation and/or reducing production of free radicals.

30. Can LDN Really Help Multiple Sclerosis?

    A growing body of research over the past 20 years indicates that your body's secretion of endorphins (your internal, natural opioids) play an important, if not central, role in the workings of your immune system. When you take LDN at bedtime (which blocks your opioid receptors for a few hours in the middle of the night) it is believed to up-regulate vital elements of your immune system by increasing your body's production of metenkephalin and endorphins, hence improving immune function.

31. Doctor Reverses MS in 9 Months by Eating a Paleo Diet (video)

    Dr. Terry Wahls tells the inspiring story of how she reversed multiple sclerosis after seven years of deterioration on the best conventional treatments available - simply by changing her diet! Dr. Wahls altered her diet to reflect the Paleo-style diet of the hunter-gatherers of old.

32. From Gout Culprit to MS Treatment?

    A new study indicates that uric acid--a compound that builds up in tissues in people with gout--prevents paralysis and death in mice with lesions resembling those seen in human MS.

33. A Double-Edged Sword: Uric Acid and Neurological Disorders

    Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received increasing attention because it was found to directly participate in the pathogenesis of many human diseases including neurological disorders.

34. First Canadian Clinical Trial Studying Ability of Mesenchymal Stem Cells to Treat Multiple Sclerosis

    Mesenchymal stem cells (MSC) – found in many places in the body including the bone marrow, skin and fat – have been demonstrated to suppress inflammation and repair nerve tissue, positioning them as promising candidates for the treatment of MS. The mechanism of action of Mesenchymal Stem Cells (MSCs) relies on their ability to modulate pathogenic immune responses and provide neuroprotection through the release of anti-apoptotic, anti-oxidant and trophic factors as demonstrated by in vitro and in vivo preclinical studies. Unlike previous studies involving transplantation of hematopoietic stem cells to re-boot the immune system, there is no requirement for chemotherapy in MESCAMS. As well, there is no concern regarding rejection of the cells as they are harvested from the individuals receiving the treatment.

35. Myelin Recovery in Multiple Sclerosis: The Challenge of Remyelination

    This review summarizes current understanding of the processes at issue: myelination, demyelination and remyelination—with emphasis upon myelin composition/architecture and oligodendrocyte maturation and differentiation.

36. Meet the Cambridge Scientist on Verge of Curing Multiple Sclerosis

    A solution could be in sight thanks to Dr Su Metcalfe, who has married one of the body's cleverest functions with some cutting-edge technology. The natural side of the equation is provided by a stem cell particle called a LIF. "I discovered a small binary switch, controlled by a LIF, which regulates inside the immune cell itself. LIF is able to control the cell to ensure it doesn't attack your own body but then releases the attack when needed." The snag is that the LIF could only survive outside the cell for 20 minutes before being broken down by the body. The solution was to combine the LIF with nanoparticles as a delivery device.

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