Hydrazine Sulfate Health Topic
Learn More About...Hydrazine Sulfate
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The Truth About Hydrazine Sulfate
Joseph Gold, M.D., director of the Syracuse Cancer Research Institute and the developer of hydrazine sulfate, speaks about its history and use as an anticachexia agent.
CONTAINS REFERENCES
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Hydrazine Sulfate Clinical Trials
A collection of articles based on published studies of hydrazine sulfate's anticachexia properties.
SCIENTIFIC STUDIES
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Syracuse Cancer Research Institute
The Syracuse Cancer Research Institute is a charitable, educational and scientific organization whose major purpose is the performance of laboratory and clinical cancer research aimed toward the innovation of new, effective treatments for cancer and the dissemination of its scientific findings and discoveries, in particular the development, clinical use, and clinical results of hydrazine sulfate.
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How Cachexia Begins
Cancer uses glucose as its fuel but only incompletely metabolizes it. The cancer's waste product—lactic acid—together with the breakdown products of other tissues of the body, are taken up by the liver and kidney and much energy is expended to convert these waste and breakdown products back into glucose. The new glucose formed may then be re-presented to the cancer cell for fuel and the cycle will be repeated. As the cancer grows, its production of lactic acid and other chemical intermediates increases, imposing on the body a condition in which the normal body energy "pools" become more and more depleted. Eventually the body reaches a point where dietary energy intake can no longer keep up with these energy losses and rapid weight loss and debilitation supervene. This is the onset of cachexia. Dr. Gold theorized that by interrupting the process which converts lactic acid into glucose, cancer cachexia could be averted.
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Hydrazine Sulfate and Cachexia
Hydrazine sulfate dramatically reverses cachexia, the wasting-away process that kills two-thirds of all cancer patients. About half of all patients who take hydrazine sulfate experience weight gain, restored appetite, and a significant reduction in pain. When cancer cells use sugar (glucose) as fuel, they only partially metabolize it. Lactic acid, the waste product of this incomplete combustion, is recycled by the liver back into glucose, and the sugar is consumed in ever-increasing amounts by voracious cancer cells. Dr. Gold chanced upon hydrazine sulfate while looking for a drug that inhibits this gluconeogenesis process. Hydrazine sulfate can shut down the enzyme necessary for the production of glucose from lactic acid.
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Warnings Concerning Hydrazine Sulfate
Hydrazine Sulfate is an MAOI (Momoamine Oxidase Inhibitor). It inhibits an enzyme that breaks down monoamines (serotonin, norepinephrine, and dopamine), those brain chemicals that make us happy. MAOs have another job in the body: they metabolize tyramine, an amino acid. When taking an MAO inhibitor, tyramine is not broken down, and eating foods with tyramine can raise your blood pressure and heart beat and cause severe headaches. Central nervous system depressants—such as barbiturates, tranquilizers and alcohol—are incompatible with MAO inhibitors and use of the two together could result in extremely dangerous effects. Includes a list of foods and medications to avoid.
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Foods to Avoid When Using Hydrazine Sulfate
If you are taking an MAO inhibitor, avoid the chemical tyramine and its precursor, tyrosine. Combining MAO inhibitors with tyramine causes the blood pressure to soar and could cause a stroke. Foods that contain tyramine include any high-protein food that has undergone aging.
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Foods Containing Tyramine
Tyramine is an amine which causes elevated blood pressure and tachycardia by displacing norepinephrine from storage vesicles. Tyramine is generally produced...during fermentation of food products. All protein-rich foods which have been matured will contain more tyramine. Most aged cheeses contain tyramine. Many processed foods contain high tyramine levels. All soy products (but mainly fermented soy products) contain high levels of tyramine.
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Low-Tyramine Diet
Many foods have a low tyramine content when fresh, but their tyramine levels rise if they are allowed to age or spoil.
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The Kathy Keeton Story
Kathy Keeton, who was a nationally recognized science journalist, co-founder of Omni and Longevity magazines, attributed her success against cancer to hydrazine sulfate.
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The Cachexia Treatment Plan
The cancer cells consume massive amounts of glucose, which consumes energy. They process the glucose with fermination, which is very inefficient. A byproduct of this fermentation is lactic acid. This lactic acid then goes into the liver. The liver then converts this lactic acid back into glucose, consuming even more energy. Much of this glucose is consumed by the cancer cells and the cycle starts over.
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Low-Tyramine Headache Diet (pdf file)
Each person may have different sensitivities to certain level of Tyramine or other vasoactive compounds in foods. If you are not on an MAO inhibitor, you should test the use of restricted foods in limited amounts.
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Allergic to Sulfa Drugs: Can You Take Sulfur?
There is a lot of understandable confusion about the difference between sulfa drugs, sulfites, sulfates and sulfur. Sulfur is the chemical element that is found in Sulfa Drugs, Sulfites, and Sulfates. Sulfur is an essential element of life and is found in amino acids and other important molecules in the body. It is IMPOSSIBLE to have a sulfur allergy. You cannot survive without sulfur. When people say that they are allergic to sulfur they mean sulfites (found in red wine) or sulfonamides (sulfa drugs), not sulfur or sulfates.
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Experience of the Treatment with Sehydrin (Hydrazine Sulfate, HS) in the Advanced Cancer Patients
The efficacy of Hydrazine Sulfate (HS) as an anticachectic drug in patients with the malignant tumours has been demonstrated. It was established in the randomized study with placebo that HS is a supplementary treatment to the combined chemotherapy of the non-small cell lung cancer that not only improved the nutritional status of patients, but also significantly prolonged the survival rates in them. Interruption of the tumour progression during the administration of Sehydrin for the period of more then 3 months was observed in 216 out of 740 patients (29.2%). The...symptomatic effects of Sehydrin were registered in 46.5% of patients. Symptom amelioration consisted of the decrease of fever, reduction or disappearance of hemoptysis, improvement of respiratory insufficiency, and frequent resolution of edema. Considerable improvement of the general state, appetite, weakness, and pain could be attributed to Sehydrin. As a rule, the improvement of the patient's general state occurred during the 2-3 weeks of treatment together with the decrease of pain, even in cases with bone metastases.
SCIENTIFIC STUDY
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